Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety
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چکیده
منابع مشابه
Cannabidiol reverses the mCPP-induced increase in marble-burying behavior.
Cannabidiol (CBD), one of the main components of Cannabis sp., presents clinical and preclinical anxiolytic properties. Recent results using the marble-burying test (MBT) suggest that CBD can also induce anticompulsive-like effects. Meta-chloro-phenyl-piperazine (mCPP) is a nonspecific serotonergic agonist (acting mainly at 5HT1A, 5HT2C and 5HT1D receptors) reported to increase symptoms in OCD ...
متن کاملEffects of Psilocybe argentipes on marble-burying behavior in mice.
Psilocybe argentipes is a hallucinogenic mushroom. The present study examined the effects of P. argentipes on marble-burying behavior, which is considered an animal model of obsessive-compulsive disorder. P. argentipes significantly inhibited marble-burying behavior without affecting locomotor activity as compared with the same dose of authentic psilocybin. These findings suggest that P. argent...
متن کاملN-acetyl-L-cysteine inhibits marble-burying behavior in mice.
In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor...
متن کاملMarble burying and nestlet shredding as tests of repetitive, compulsive-like behaviors in mice.
Obsessive-compulsive disorder (OCD) and autism spectrum disorders (ASD) are serious and debilitating psychiatric conditions and each constitutes a significant public health concern, particularly in children. Both of these conditions are highlighted by the repeated expression of meaningless behaviors. Individuals with OCD often show checking, frequent hand washing, and counting. Children with AS...
متن کاملLow dose effects of a Withania somnifera extract on altered marble burying behavior in stressed mice
AIM Withania somnifera root (WSR) extracts are often used in traditionally known Indian systems of medicine for prevention and cure of psychosomatic disorders. The reported experiment was designed to test whether low daily oral doses of such extracts are also effective in suppressing marble burying behavior in stressed mice or not. MATERIALS AND METHODS Groups of mice treated with 10, 20, or ...
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ژورنال
عنوان ژورنال: Psychopharmacology
سال: 2009
ISSN: 0033-3158,1432-2072
DOI: 10.1007/s00213-009-1466-y